Battle Between MicroRNAs and Scar Formation During Wound Healing


Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, IR Iran



Wound healing is defined as a regular step by step process leading to full recovery of a wound. However, in many cases, scar formation influences the full repair of the wound area. When healing is completed, there is no foot print in the wound area, but in some cases a scar can be formed and affect full recovery. A molecular view of scar formation specifies that there is an unbalanced expression of some genes, which leads to incomplete healing and the formation of scars in the wound location. During the past decade, similar to many regulators, microRNAs (miRNAs) have been found to play an effective role in this process; in particular, their effect on the TGF-β family has been heavily studied and is now well understood. The purpose of this article is to review recent research on the interaction between miRNAs and scar formation during wound healing.